Acne scars remain one of the most common skin concerns in Singapore, particularly atrophic acne scars such as rolling, boxcar, and shallow depressions, along with overall uneven skin texture that can make the complexion look tired or less smooth. In recent years, there has been growing interest in Rejuran PN (polynucleotide-based skin treatment) as a regenerative approach that focuses not just on surface improvement, but on supporting the skin’s natural healing and repair processes from within. 

Unlike conventional treatments that primarily resurface or fill scars, Rejuran is often explored for its potential role in improving overall skin quality, resilience, and texture over time. This article will explore whether rejuran can truly help with acne scars and uneven skin texture, and how it fits into modern scar management strategies. Read more for further details.

What Is Rejuran PN (Polynucleotides)?

Rejuran PN is a skin treatment based on polynucleotides (PN), which are biologically derived DNA fragments commonly sourced from salmon. These polynucleotides are biocompatible with human skin and are designed to support the skin’s natural repair and regeneration processes. In aesthetic medicine, Rejuran is widely discussed for its role in improving overall skin health rather than simply targeting individual imperfections.

At a biological level, polynucleotides work by helping to create a healthier dermal environment. They are believed to support fibroblast activity, which is responsible for producing collagen and maintaining skin structure. Over time, this can contribute to improved skin elasticity, hydration balance, and dermal density. Instead of acting as a volumising or surface-level corrective treatment, Rejuran PN is positioned as a regenerative skin booster that works gradually from within the skin layers.

How Rejuran PN Works on Acne Scars

Rejuran PN does not physically “fill” acne scars in the way dermal fillers do, but it works by improving the underlying skin quality that contributes to how scars appear. Acne scars, especially atrophic types, are often the result of collagen loss and disrupted skin healing after inflammation. Rejuran PN aims to address this by supporting the skin’s natural repair mechanisms.

Polynucleotides in Rejuran are thought to stimulate fibroblast activity, which plays a key role in collagen production and dermal remodeling. As the skin gradually repairs itself, there may be an improvement in skin thickness, elasticity, and overall texture. This can make shallow acne scars appear softer and less noticeable over time.

In addition, Rejuran PN may help improve the skin’s healing environment by supporting hydration and reducing ongoing micro-inflammation. While it is not a standalone scar removal treatment, it is often used as part of a broader acne scar management plan to enhance overall skin quality and complement other procedures such as laser or microneedling.

Types of Acne Scars That May Respond to Rejuran PN

Rejuran PN tends to work best on acne scars related to skin quality and mild structural damage rather than deep, fixed scarring. Its effects are gradual and linked to overall dermal regeneration and improved skin texture.

• Atrophic scars (rolling, shallow boxcar scars): May improve in appearance as skin becomes smoother and more elastic
• Post-inflammatory uneven texture: Can benefit from enhanced skin healing and improved surface refinement
• Enlarged pores with acne history: May appear less prominent as skin quality improves
• Deep ice-pick scars: Usually show limited response and require other targeted treatments

Overall, this treatment is better suited for improving global skin texture and quality, rather than fully correcting deep acne scar depressions. It is often used as part of a combined treatment approach for best results.

Rejuran PN vs Other Acne Scar Treatments

Rejuran PN is often compared with more traditional acne scar treatments, but it works in a fundamentally different way. Instead of directly reshaping scar tissue, it focuses on improving the skin’s biological healing capacity and overall dermal quality.

Procedures such as fractional CO2 laser or Pico laser primarily target resurfacing the skin and stimulating controlled injury to trigger collagen remodeling. These methods can be more effective for visible scar depth reduction, especially in moderate to severe cases. Microneedling and RF microneedling also create controlled micro-injuries to encourage collagen formation, often with more direct impact on scar texture.

In contrast, Rejuran PN is better understood as a bioregenerative skin booster. It is frequently used as a complementary treatment to enhance healing, improve skin resilience, and support results from energy-based or mechanical scar treatments, rather than replacing them entirely.

Treatment Process and What to Expect

Rejuran PN is administered through a series of small intradermal injections delivered across the treatment area, typically targeting regions affected by acne scars or overall skin texture concerns. The technique is designed to place polynucleotides directly into the dermal layer where skin repair and collagen activity occur.

During the procedure, a numbing cream is often applied beforehand to improve comfort. Patients may still feel mild discomfort or a stinging sensation during injections. After treatment, it is common to see small raised bumps, mild redness, or slight swelling at the injection sites. These effects are generally temporary and usually settle within 1 to 3 days.

Conclusion

Rejuran PN offers a regenerative approach to acne scar management by focusing on improving overall skin quality, texture, and dermal health rather than directly filling or removing scars. It may be particularly helpful for mild to moderate atrophic scars and uneven skin texture, especially when used as part of a broader treatment plan that may include lasers or other scar-targeting procedures. 

While results vary depending on scar type and severity, improvements are typically gradual and build over time with consistent treatment. To find out whether Rejuran PN is suitable for your acne scars and skin concerns, you may book a consultation at::

Edwin Lim Medical Aesthetic Clinic – Pigmentation Treatment | Acne Scar Removal Singapore

Changi City Point
#02-12/13 Changi City Point, 5 Changi Business Park Central 1, 486038

Phone: +65 69042218

https://edwinlimclinic.sg/